|Pimozide - is
an anti-psychotic drug belonging to the di phenyl butylpiperidine group.
Structurally it is similar to the butyrophenones, another very well known
group of antipsychotic drugs that includes haloperidol. Pimozide exerts
its anti-psychotic action by blocking pre and post synaptical central dopaminergic
it is an iminodibenzylic drug. Firstly used to treat epilepsy, it is now
employed in cases of mood disorders (manic episodes, depression, bipolar
disorders) and in schizoaffective disorders. Its therapeutical effects
are due to actions on peripheral benzodiazepinic receptors connected to
calcium channels, to potentiation of alpha 2 adrenergic receptors or to
neuronal sodium channel stabilization.
Clonazepam - a
benzodiazepinic drug that acts on receptors associated with GABA receptors
and chloride ion channels. Like all the other members of this chemical
family, clonazepam potentiates the effects of GABA on its receptor, thus
increasing the influx of chloride ions to the neuron. Clonazepam is used
in the treatment of epileptic attacks, panic disorders, social phobias
and mood disorders ( acute mania and bipolar disorders).